fig2

Figure 2. Prediction of mechanisms through which MeCP2 regulates miRNAs in oligodendrocyte lineage cells. MeCP2 may regulate the expression of miRNA through two pathways in the nucleus. The first way is that MeCP2 can directly bind to the mCG site of the miRNA gene promoter to inhibit transcription. The second way is that MeCP2 can affect the number of Dorsha complexes by controlling the binding of the Dorsha and DGCR8. Dorsha complexes can cleave pri-miRNAs to generate pre-miRNAs. MeCP2 regulates the expression of pre-miRNAs in the nucleus and then inhibits the translation of downstream target mRNAs by affecting the expression levels of intracellular miRNAs. Black arrows indicate downregulation, and red arrows indicate upregulation.