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![Newly identified transmembrane protein 106B amyloid fibrils in the human brain: pathogens or by-products?](https://image.oaes.cc/e62600e1-9f97-402a-aeb7-48a68df3e754/5491.fig.2.jpg)
Figure 2. Comparison of the structural polymorphism of amyloid fibrils formed by tau, α-syn, and TMEM106B. The topology diagrams show different polymorphic structures of brain-extracted tau fibrils (A), brain-extracted and in vitro assembled α-syn fibrils (B), and brain-extracted TMEM106B fibrils (C). AD: Alzheimer’s disease; ALS: amyotrophic lateral sclerosis; CBD: corticobasal degeneration; CTE: chronic traumatic encephalopathy; DLB: dementia with Lewy bodies; FTLD: frontotemporal lobar degeneration; MSA: multiple system atrophy; PD: Parkinson's disease; PDD: Parkinson's disease with dementia; PiD: Pick's disease; PSP: progressive supranuclear palsy.