fig1

Figure 1. Overview of the mechanism by which ACSL4-mediated neuronal cell ferroptosis augments CD4⁺ T-cell activation and EAE progression. HMGB1: High-mobility group box 1 protein; CRT: calreticulin; 8-OHG: 8-hydroxy-2’-deoxyguanosine; SAPE-OOH: 1-steaoryl-2-15-HpETE-sn-glycero-3-phosphatidylethanolamine; TCR: T-cell receptor; CD4: cluster of differentiation 4; p-Akt: phosphorylated protein kinase B; p-Erk: phosphorylated extracellular signal-regulated kinase; EAE: experimental autoimmune encephalitis.