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Figure 2. Profound motor abnormalities of G59S Tg and G71R Tg mice. (A-D) At 1, 6, 12, and 18 months of age, cohorts of male nTg, tTA, tetO-WT, and WT Tg mice (n = 10 per genotype) were repeatedly weighed (A); tested for ambulatory movement (B) and rearing (C) in the open-field test; and examined for the latency to fall in the rotarod test (D). (E-H) At 1, 6, 12, and 18 months of age, cohorts of male nTg (n = 10), tTA (n = 11), tetO-G59S (n = 10), and G59S Tg (n = 10) mice were repeatedly weighed (E); tested for ambulatory movement (F) and rearing (G) in the open-field test; and examined for the latency to fall in the rotarod test (H). (I-L) At 1, 6, 12, and 18 months of age, cohorts of male nTg (n = 11), tTA (n = 10), tetO-G71R (n = 10), and G71R Tg (n = 10) mice were repeatedly weighed (I); tested for ambulatory movement (J) and rearing (K) in the open-field test; and examined for the latency to fall in the rotarod test (L). Data are presented as mean ± SEM. Two-way ANOVA with Tukey’s multiple comparisons test was used for statistical analysis (at each time point, the mean of each genotype was compared with the mean of every other genotype). ^*P < 0.05, ^**P < 0.01, ^****P < 0.0001.