fig7
Figure 7. Influence of the size of dogs on the retinal deposition of amyloid-beta oligomers (Aβo), plaques (Aβp), and phosphorylated tau (p-Tau) in cognitively unimpaired young (1-5-years), middle (6-10-years) and old (11-16-years) age groups of dogs. PRIOAD12 (Aβ40 oligomers), PRIOAD13 (Aβ42 oligomers), 4G8 (Aβp), and AT8 (p-Tau) fluorescence immunoreactivity and intensities were examined and quantified at 40× magnification under the fluorescence microscope. In three different age groups, semiquantitative analyses were compared with the size of the dogs. In young dogs, a large number of oligomers were displayed by the small and big size dogs. The majority of medium-sized dogs displayed strong Aβo and Aβp staining intensity in the middle-aged dogs. Finally, among the different sizes of old dogs, medium-sized breeds displayed the highest amount of Aβo, Aβp, and p-Tau staining intensity.
