fig1

Figure 1. Factors responsible for circadian misalignment in liver metabolism. SCN: Suprachiasmatic nucleus; ZT: zone time; Per 1: period circadian regulator 1; Per 2: period circadian regulator 2; FXR: farnesoid X receptor; Cyp7A1: cholesterol 7 alpha-hydroxylase; BMAL1: basic helix-loop-helix ARNT Like 1; CLOCK: circadian locomotor output cycles kaput; GLUT2: glucose transporter 2; GYS: glycogen synthase; GSK3: glycogen synthase kinase-3; InsR: insulin receptor; Cry1: circadian cryptochrome; AKT: protein kinase B; GLUT 4: glucose transporter 4; PPARs: peroxisome proliferator-activated receptors; SREBP: sterol regulatory element-binding protein; Rev-Erb : NR1D (nuclear receptor subfamily 1 group D); FA: fatty acid; ER: endoplasmic reticulum; ROS: reactive oxygen species.