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![The role of exosomes in therapeutic resistance of hepatocellular carcinoma](https://image.oaes.cc/21d7600c-63e3-4019-9b4d-c40430582ebf/hr9085.fig.1.jpg)
Figure 1. Representative mechanisms of exosome-mediated drug resistance in HCC. Exosomes derived from cells in TME serve as mediators to transport functional cargos that subsequently influence the signaling pathways and characteristics of target cells. HCC: hepatocellular carcinoma; CMA: Chaperone-mediated autophagy; BMMSCs: bone marrow-derived mesenchymal stem cells; EMT: Epithelial-Mesenchymal Transition; TAM, tumor-associated macrophage.