fig1
![Cholangiocarcinoma tumor microenvironment highlighting fibrosis and matrix components](https://image.oaes.cc/769e48b1-4a8c-47c5-92f8-e91e1abf89bc/HR-2023-23.fig.1.jpg)
Figure 1. Role of CAFs in CCA progression. Functional crosstalk between CCA cancer cells and CAFs from a cancer mechanics perspective. As mentioned and described in the review text, CAFs affect the tumor microenvironment, modulating ECM remodeling, angiogenesis and lymphangiogenesis, metastasis and immune evasion, and then provide a microenvironment favorable to CCA progression.