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Figure 3. Overview of cancer immunity cycle in post-locoregional therapy. Locoregional therapies generate cytotoxic CD8⁺ T cells that enhance the destruction of local and systemic cancers. Tumor destruction by locoregional therapy results in the release of several tumor antigens that can be processed by antigen-presenting cells and presented to naive T cells through major histocompatibility complex (MHC) class I molecules. The simultaneous release of DAMPs induces an adaptive immune response. Tumor-specific cytotoxic T cells were activated and proliferated in the lymph nodes, and then migrated into the circulatory system. APC: antigen-presenting cells; DAMPs: damage-associated molecular patterns; IFN-γ: interferon-gamma; Gzmb: granzyme B; TNF-α: tumor necrosis factor-alpha. Figure reprinted with copyright permission from reference^[40].