fig1

Figure 1. The BCLC system establishes a prognosis in accordance with the 5 stages that are linked to first-line treatment recommendation. The expected outcome is expressed as the median survival of each tumor stage according to the available scientific evidence. Individualized clinical decision-making, according to the available data on November 15, 2021, is defined by teams responsible for integrating all available data with the individual patient’s medical profile. Note that liver function should be evaluated beyond the conventional Child-Pugh staging. AFP: alpha-fetoprotein; ALBI: albumin-bilirubin; BCLC: Barcelona Clinic Liver Cancer; BSC: best supportive care; ECOG-PS: Eastern Cooperative Oncology Group performance status; LT: liver transplantation; MELD: model of end-stage liver disease; TACE: transarterial chemoembolization. Figure reprinted with copyright permission from reference^[4].