fig7

From: MASLD-mimicking microenvironment drives an aggressive phenotype and represses IDH2 expression in hepatocellular carcinoma

Figure 7. (A and B) Expression analysis of IDH2 in mRNA and protein level (A) TCGA-LIHC; P = 7.11 E-01; n: tumor = 371, normal = 50 and (B) CPTAC-LIHC; P = 4.52 E-34 n: tumor = 165 normal = 165 Graphs were generated by UALCAN. (C-H) Analysis of differentially expressed (DE) genes and clinical characterizations in Low-IDH2 vs. High-IDH2 tumors in TCGA cohort (C)Volcano graph of DE genes. Statistically significant DE genes are represented by blue dots (P 2) (D) Progress-free survival of patients in Low-IDH2 and High-IDH2 expressed groups. Low-IDH2 patients’ (E) Histologic grade; (F) Aneuploidy score; (G) Hypoxia score; and (H) Fraction genome altered of tumors are higher than High-IDH2 patients. Graphs were generated by cBioPortal.