fig6

MASLD-mimicking microenvironment drives an aggressive phenotype and represses IDH2 expression in hepatocellular carcinoma

Figure 6. Expression analysis of IDH2 in SNU-449 cells by (A) WB (B) RT-qPCR (C) Flow Cytometry in control and MM conditions. Protein expressions of IDH2 in HuH-7 cells by (D) WB in control and MM conditions. In silico validation/analysis of IDH2 expression in open-access datasets; (E) GSE164441 and (F) E-MEXP-3291. IDH2 expression of motile and non-motile SNU-449 cells in control (G) and MM conditions (H) (Unpaired t-test, ns: nonsignificant, *P < 0.05, **P < 0.01). IDH2:Isocitrate Dehydrogenase (NADP(+))2; MM: metabolic medium; NAFLD: non-alcoholic fatty liver disease; HCC: hepatocellular carcinoma; NASH: non-alcoholic steatohepatitis

Hepatoma Research
ISSN 2454-2520 (Online) 2394-5079 (Print)

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