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![Assessment of response to liver directed radiation-based therapies: Current guidelines, challenges, and future directions](https://image.oaes.cc/2873b637-e4cb-4913-b722-470f11e30900/5378.fig.4.jpg)
Figure 4. 65-year-old male, hepatitis C cirrhosis, arterial phase MR images. Pretreatment image shows a 2.1 LR-5 observation with APHE and washout (not shown), consistent with HCC. Three- and seven months follow-up image after Y-90 shows peripheral APHE along the treatment zone (arrows), most likely related to hyperemic response, progressive tumor response with granulation tissue and fibrosis development.