fig1

Figure 1. Cholangiocarcinoma classification includes intrahepatic, hilar, and extrahepatic or distal subgroups. The majority of cholangiocarcinomas arise from perihilar or distal ducts, while less than 10% are from intrahepatic ducts. Additionally, through improved genetic analysis, there is a better understanding of the shared and distinct somatic genomic landscapes of cholangiocarcinoma and possible actionable mutation for which therapies may exist.