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![Treatment of advanced biliary tract cancers: from chemotherapy to targeted agents](https://image.oaes.cc/f7c96dd1-4979-4cd3-9929-d95660cf6b88/4437.fig.3.jpg)
Figure 3. Overall survival of chemorefractory aBTC. Figure 3 shows overall survival (OS) of chemorefractory aBTCs from pooled analysis of ABCs studies and second line clinical trials. ABCs studies include ABC-01, -02 and -03 clinical trials which explored the role of first-line systemic chemotherapy in advanced BTCs [cisplatin and gemcitabine vs. gemcitabine (ABC-01 and ABC-02) and cisplatin-gemcitabine-cediranib vs. cisplatin-gemcitabine-placebo (ABC-03)]. ASC: Active symptom control; PBO: placebo; FGF: fibroblast growth factor; FGFR: fibroblast growth factor receptor; IDH-1: isocitrate dehydrogenase 1; CCA: cholangiocarcinoma; BTCs: biliary tract cancers; aBTCs: advanced biliary tract cancers; 5FU/LV: 5-fluorouracil plus leucovorin; nal-IRI: fluorouracil and liposomial irinotecan; mFOLFOX: 5-fluorouracil plus oxaliplatin.