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![Treatment of advanced biliary tract cancers: from chemotherapy to targeted agents](https://image.oaes.cc/f7c96dd1-4979-4cd3-9929-d95660cf6b88/4437.fig.1.jpg)
Figure 1. Evolution of systemic treatments of aBTCs. aBTCs: Advanced biliary tract cancers; L: line; ICIs: immune checkpoint inhibitors; m: mutations; f: fusions; a: amplifications; italic: under current clinical investigation; CISGEM: cisplatin + gemcitabine; FOLFOX: 5-fluorouracil + folinic acid + oxaliplatin; Nal-IRI: nanoliposomal irinotecan; FOLFIRINOX: 5-fluorouracil + folinic acid + oxaliplatin + irinotecan; PARPi: poly-ADP ribose polymerase inhibitors.