fig4

Figure 4. Histological grading of hepatocellular carcinoma according to World Health Organization. (A) Well differentiated hepatocellular carcinoma: thin trabecular structures and minimal atypia of tumor cells resembling mature hepatocytes. (B) Moderately differentiated hepatocellular carcinoma: trabecular pattern with at least 3 cells in thickness, moderate nuclear atypia with increased nuclear:cytoplasma ratio, microvesicular fatty changes (lower left). (C) Poorly differentiated hepatocellular carcinoma: marked pleomorphic tumor cells with fatty changes, prominent nucleoli und anaplastic giant cells.