fig1

Figure 1. The p53 family - a complex expression strategy. A: schematic representation of the exon structure of TP53, TP63 and TP73 genes. The position of the P1 promoter and the internal P2 promoter relative to the exons in the 3 genes are indicated. p53 gene transcription is initiated from two distinct sites (P1 and P1′); B: p53, p63 and p73 protein domains. TAD: N-terminal transactivation domains (yellow); PR: proline-rich sequence (grey); DBD: DNA-binding domain (purple); OD: C-terminal oligomerization domain (green); SAM: sterile alpha motif (dark blue); post-SAM: post-sterile alpha motif (burgundy). The principal N-terminal truncated isoforms (ΔTA or ΔN), generated by the use of internal promoters (P2), alternative splicing of the first exons or the use of alternative translation start sites, and the COOH-terminal variants α, β, γ, δ, ε, ζ, generated by alternative splicing of p53, p63 and p73 are also indicated