fig5
Figure 5. Autoradiograph of results of analysis of RNA (Northern) from organs of mice treated intraperitoneally with different amounts of E. Coli LPS as a model to induce an acute-phase reaction. The filters containing the tissue-RNA were hybridised with radio-actively labelled cDNAs specific for factor B, for SAA and for actin as control. In all organs factor B- and SAA-gene-expression was up-regulated in a dose-dependent manner. The different time of exposure of the x-ray film demonstrate the different abundance of gene-expression of factor B and SAA in the different organs. SAA: serum amyloid A; LPS: lipolysaccharide. J Immunol 1985;135:3645-7. (reprinted with permission)[63]