fig1

Figure 1. Schematic diagram of multistep hepatocarcinogenesis. Two types of human hepatocarcinogenesis are currently considered, one is multistep- and the other is de novo-hepatocarcinogenesis. In multistep hepatocarcinogenesis, the nodular grade of malignancy changes from dysplastic nodule to advanced HCC stepwisely, and nodular vascularity also gradually change from hypovascular to hypervascular. HCC: hepatocellular carcinoma