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![Intraarterial and intravenous contrast enhanced CT and MR imaging of multi-step hepatocarcinogenesis defining the early stage of hepatocellular carcinoma development](https://image.oaes.cc/ba4a9e93-71c8-4862-8d25-926f6076a4ec/3502.fig.1.jpg)
Figure 1. Schematic diagram of multistep hepatocarcinogenesis. Two types of human hepatocarcinogenesis are currently considered, one is multistep- and the other is de novo-hepatocarcinogenesis. In multistep hepatocarcinogenesis, the nodular grade of malignancy changes from dysplastic nodule to advanced HCC stepwisely, and nodular vascularity also gradually change from hypovascular to hypervascular. HCC: hepatocellular carcinoma