fig3

Figure 3. Adjusted hazards ratio of risk of de novo HCC in DAA- vs. IFN-treated populations. The multivariate-adjusted hazard ratio of each individual study is represented by the blue square with the size of the square being proportional to the n of the study. The thin horizontal grey bars represent the 95%CI of each study and the thick vertical blue line marks where the HR is equal to 1. The red diamond with the dashed vertical red line is the overall adjusted HR, which was 0.58 (95%CI: 0.20, 1.07) for de novo HCC in the DAA population compared to the IFN-treated population. HCC: hepatocellular carcinoma; IFN: interferon; CI: confidence interval