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![Liver carcinogenesis: diagnostic and clinical aspects of preneoplastic nodules](https://image.oaes.cc/cd5257f8-3e87-4358-8b8c-186cc4f6f063/3074.fig.2.jpg)
Figure 2. Schematic illustration of adequacy judgement of liver biopsy for small nodules in cirrhosis. Intra- and extra-lesion samples are mandatory. Schematically, adequacy can be checked by evaluating the overall nodularity at low magnification by comparing intra- and extranodular biopsy samples. When both intra- and extra-lesional samples show overlapping cirrhosis-like features, without a major nodule in the background, the sample should not be considered adequate and biopsy should be repeated shortly after