fig2

Figure 2. Schematic illustration of adequacy judgement of liver biopsy for small nodules in cirrhosis. Intra- and extra-lesion samples are mandatory. Schematically, adequacy can be checked by evaluating the overall nodularity at low magnification by comparing intra- and extranodular biopsy samples. When both intra- and extra-lesional samples show overlapping cirrhosis-like features, without a major nodule in the background, the sample should not be considered adequate and biopsy should be repeated shortly after