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![Somatostatin in hepatocellular carcinoma: experimental and therapeutic implications](https://image.oaes.cc/dbb335ff-07ae-4760-8920-80bda2bf8d9b/2675.fig.1.png)
Figure 1. Anti-tumoral effect of somatostatin is achieved through various cellular pathways leading to inhibition of cell proliferation, inflammation, fibrosis and angiogenesis. Apoptosis is increased. It seems that a reduction of tumor associated macrophages (TAM) and a swift from M2 polarization in Kupffer cells may also help in the final effect