REFERENCES

1. Chisari FV, Isogawa M, Wieland SF. Pathogenesis of hepatitis B virus infection. Pathol Biol (Paris) 2010;58:258-66.

2. Chan SL, Wong VW, Qin S, Chan HL. Infection and cancer: the case of hepatitis B. J Clin Oncol 2016;34:83-90.

3. Hou JL, Wei L; Chinese Society of Hepatology, Chinese Society of Infectious Diseases; Chinese Medical Association. The guideline of prevention and treatment forchronic hepatitis B: a 2015 update. Chin J Hepato (Zhonghua GanZang Bing Za Zhi) 2015;23:888-905. (in Chinese)

4. Quasdorff M, Protzer U. Control of hepatitis B virus at the level of transcription. J Viral Hepat 2010;17:527-36.

5. Stahl M, Beck J, Nassal M. Chaperones activate hepadnavirus reverse transcriptase by transiently exposing a C-proximal region in the terminal protein domain that contributes to epsilon RNA binding. J Virol 2007;81:13354-64.

6. Wang J, Yu Y, Li G, Shen C, Meng Z, et al. Relationship between serum HBV-RNA levels and intrahepatic viral as well as histologic activity markers in entecavir-treated patients. J Hepatol 2018;68:16-24.

7. Halgand B, Desterke C, Rivière L, Fallot G, Sebagh M, et al. Hepatitis B virus pregenomic RNA in hepatocellular carcinoma: a nosological and prognostic determinant. Hepatology 2018;67:86-96.

8. Wang J, Shen T, Huang X, Kumar GR, Chen X, et al. Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound. J Hepatol 2016;65:700-10.

9. Hong X, Kim ES, Guo H. Epigenetic regulation of hepatitis B virus covalently closed circular DNA: implications for epigenetic therapy against chronic hepatitis B. Hepatology 2017;66:2066-77.

10. Block TM, Guo H, Guo JT. Molecular virology of hepatitis B virus for clinicians. Clin Liver Dis 2007;11:685-706.

11. Jones SA, Hu J. Hepatitis B virus reverse transcriptase: diverse functions as classical and emerging targets for antiviral intervention. Emerg Microbes Infect 2013;2:e56.

12. Stahl M, Beck J, Nassal M. Chaperones activate hepadnavirus reverse transcriptase by transiently exposing a C-proximal region in the terminal protein domain that contributes to epsilon RNA binding. J Virol 2007;81:13354-64.

13. Prange R. Host factors involved in hepatitis B virus maturation, assembly, and egress. Med Microbiol Immunol 2012;201:449-61.

14. Wang S, Qiu L, Yan X, Jin W, Wang Y, et al. Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity. Hepatology 2012;55:730-41.

15. Deng M, Hou J, Hu J, Wang S, Chen M, et al. Hepatitis B virus mRNAs functionally sequester let-7a and enhance hepatocellular carcinoma. Cancer Lett 2016;383:62-72.

16. Li C, Wang Y, Wang S, Wu B, Hao J, et al. Hepatitis B virus mRNA-mediated miR-122 inhibition upregulates PTTG1-binding protein, which promotes hepatocellular carcinoma tumor growth and cell invasion. J Virol 2013;87:2193-205.

17. Wang Y, Jiang L, Ji X, Yang B, Zhang Y, et al. Hepatitis B viral RNA directly mediates down-regulation of the tumor suppressor microRNA miR-15a/miR-16-1 in hepatocytes. J Biol Chem 2013;288:18484-93.

18. Yang X, Li H, Sun H, Fan H, Hu Y, et al. Hepatitis B virus-encoded microRNA controls viral replication. J Virol 2017;91:01919-16.

19. Yin S, Fan Y, Zhang H, Zhao Z, Hao Y, et al. Differential TGF-β pathway targeting by miR-122 in humans and mice affects liver cancer metastasis. Nat Commun 2016;7:11012.

20. Sato S, Li K, Kameyama T, Hayashi T, Ishida Y, et al. The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus. Immunity 2015;42:123-32.

21. Breitkreutz R, Zhang W, Lee M, Hoffmann A, Tokus M, et al. Hepatitis B virus nucleic acids circulating in the blood: distinct patterns in HBs carriers with hepatocellular carcinoma. Ann N Y Acad Sci 2001;945:195-206.

22. Hilger C, Velhagen I, Zentgraf H, Schroder CH. Diversity of hepatitis B virus X gene-related transcripts in hepatocellular carcinoma: a novel polyadenylation site on viral DNA. J Virol 1991;65:4284-91.

23. Takata A, Otsuka M, Ohno M, Kishikawa T, Yoshikawa T, et al. Mutual antagonism between hepatitis B viral mRNA and host microRNA let-7. Sci Rep 2016;6:23237.

24. Giersch K, Allweiss L, Volz T, Dandri M, Lutgehetmann M. Serum HBV pgRNA as a clinical marker for cccDNA activity. J Hepatol 2017;66:460-2.

25. Sarin SK, Kumar M, Lau GK, Abbas Z, Chan HL, et al. Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update. Hepatol Int 2016;10:1-98.

26. Lampertico P, Agarwal K, Berg T, Buti M, Janssen HLA, et al; European Association for the Study of the Liver. EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection. J Hepatol 2017;67:370-98.

27. Terrault NA, Bzowej NH, Chang KM, Hwang JP, Jonas MM, et al; American Association for the Study of Liver Diseases. AASLD guidelines for treatment of chronic hepatitis B. Hepatology 2016;63:261-83.

28. Jansen L, Kootstra NA, van Dort KA, Takkenberg RB, Reesink HW, et al. Hepatitis B virus pregenomic RNA is present in virions in plasma and is associated with a response to pegylated interferon Alfa-2a and uucleos(t)ide analogues. J Infect Dis 2016;213:224-32.

29. van Bommel F, Bartens A, Mysickova A, Hofmann J, Kruger DH, et al. Serum hepatitis B virus RNA levels as an early predictor of hepatitis B envelope antigen seroconversion during treatment with polymerase inhibitors. Hepatology 2015;61:66-76.

30. van Bommel F, van Bommel A, Krauel A, Wat C, Pavlovic V, et al. Serum HBV RNA as a predictor of peginterferon Alfa-2a (40KD) response in patients with HBeAg-positive chronic hepatitis B. J Infect Dis 2018;218:1066-74.

31. Huang YW, Takahashi S, Tsuge M, Chen CL, Wang TC, et al. On-treatment low serum HBV RNA level predicts initial virological response in chronic hepatitis B patients receiving nucleoside analogue therapy. Antivir Ther 2015;20:369-75.

32. Wang J, Du M, Huang H, Chen R, Niu J, et al. Reply to: “Serum HBV pgRNA as a clinical marker for cccDNA activity”: Consistent loss of serum HBV RNA might predict the “para-functional cure” of chronic hepatitis B. J Hepatol 2017;66:462-3.

33. Tsuge M, Murakami E, Imamura M, Abe H, Miki D, et al. Serum HBV RNA and HBeAg are useful markers for the safe discontinuation of nucleotide analogue treatments in chronic hepatitis B patients. J Gastroenterol 2013;48:1188-204.

34. Kock J, Theilmann L, Galle P, Schlicht HJ. Hepatitis B virus nucleic acids associated with human peripheral blood mononuclear cells do not originate from replicating virus. Hepatology 1996;23:405-13.

35. Su Q, Wang SF, Chang TE, Breitkreutz R, Hennig H, et al. Circulating hepatitis B virus nucleic acids in chronic infection : representation of differently polyadenylated viral transcripts during progression to nonreplicative stages. Clin Cancer Res 2001;7:2005-15.

36. Hacker HJ, Zhang W, Tokus M, Bock T, Schroder CH. Patterns of circulating hepatitis B virus serum nucleic acids during lamivudine therapy. Ann N Y Acad Sci 2004;1022:271-81.

37. Kairat A, Beerheide W, Zhou G, Tang ZY, Edler L, et al. Truncated hepatitis B virus RNA in human hepatocellular carcinoma: its representation in patients with advancing age. Intervirology 1999;42:228-37.

Hepatoma Research
ISSN 2454-2520 (Online) 2394-5079 (Print)

Portico

All published articles are preserved here permanently:

https://www.portico.org/publishers/oae/

Portico

All published articles are preserved here permanently:

https://www.portico.org/publishers/oae/