fig4

Figure 4. Maintained activity by soluble interleukin 6 receptor (sIL-6R); ligation of IL-6 with its membrane binding protein (IL-6R) results in association of the complex with a 130 kDa signal transduction glycoprotein (gp130). When cleaved from the cell surface, the IL-6/sIL-6R complex remains able to bind and activate gp130