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![Human telomerase disease mutants and its relation with hepatocarcinoma](https://image.oaes.cc/31cb694d-6c7b-4e7b-a526-17b73f7aa77e/1467.fig.1.png)
Figure 1. The structural scheme for the four domains of the telomerase reverse transcriptase (TERT) protein with mutations. TERT is composed of four structural domains: telomerase essential N-terminal (TEN), telomerase RNA binding domain (TRBD), reverse transcriptase (RT), and C-terminal extension (CTE). The above structure has indicated the locations of mutations known to cause human diseases.