fig4

Knockdown of the <i>EEF1A2</i> gene reduces lung cancer brain metastasis by downregulating the <i>BCL10/NFκB</i> pathway

Figure 4. Knockdown of EEF1A2 reduces the expression of BCL10, NFκB and EMT-related molecules. (A) Volcano plots showing differentially expressed proteins (DEPs) in EEF1A2-knockdown PC9 cells. (B) Heatmaps demonstrating the top 30 up- and downregulated proteins. (C) KEGG analysis revealing the functional enrichment of 528 DEPs. (D-G) Western blot analysis of EEF1A2, BCL10, EGFR, phosphorylated EGFR (phospho-EGFR), NFκB, phosphorylated NFκB (phospho-NFκB), N-cadherin, E-cadherin, Twist, Snail + Slug, and Cdc42 in EEF1A2-knockdown PC9 and SPCA1 cells.

Journal of Cancer Metastasis and Treatment
ISSN 2454-2857 (Online) 2394-4722 (Print)

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https://www.portico.org/publishers/oae/