fig4
From: The role of PD-1/PD-L1 signaling pathway in cancer pathogenesis and treatment: a systematic review
Figure 4. The EGF binds with its receptor and, through a cascade of reactions via activation of 3 pathways, consequently induces transcription of the PD-L1 gene; (1) c-Cbl activates NCK and then activates JNKs, and finally, transcription of PD-L1 gene is induced via activation of c-Jun. (2) JAK2/STAT1 pathway induces transcription of PD-L1 gene. (3) Ras-BRAF-MEK-ERK induces PDL1 transcription.
