fig3
From: The role of PD-1/PD-L1 signaling pathway in cancer pathogenesis and treatment: a systematic review
Figure 3. PD-1/PD-L1 pathway concerning other signaling mechanisms. JAK/STAT3 may upregulate PD-1 expression in T cells, while on the other hand, PI3K/AKT, JAK/STAT3, MAPK, and NFKβ pathways may lead to PD-L1 upregulation.
