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Figure 4. Histopathology of intratibial tumors and abdominal pathological changes in control (n = 8) and treated (n = 4) male, 11-week-old nude mice. Intratibial tumors that grew in the metaphyses of control (A) and treated (B) mice were microscopically similar (H&E stain; original magnification 10x). Central areas contained tumor cell necrosis and fragments of necrotic, lamellar trabecular bone (*). Scale bar: 100 µm; (C) Ileum from a control mouse (H&E stain; original magnification: 20x); (D) Ileum from a DRB18-treated mouse at day 21 with serosal fibrosis (blue vertical bar; H&E stain; original magnification: 20x). Scale bar: 50 µm.