fig3

Figure 3. (A) Fabrication procedures and antitumor mechanisms of BCFe@SRF nanoreactor for the designed synergistic PDT and ferroptosis therapy; (B) TEM images of a BSA-Ce6, BCFe@SRF, and BCFe@SRF degradation product; (C) A CCK-8 cell viability assay of hepa 1-6 cells treated with BCFe@SRF (Ce6 concentration: 1 μM) mediated PDT (670 nm light, 50 mW·cm^-2, 5 min) in normoxic or hypoxia condition; (D) Live/dead staining assay (green: live cells; red: dead cells); (C) CCK-8 cell viability assay; (E) CCK-8 cell viability assay; (F) Fluorescence microscopy images of hepa 1-6 cells treated with different formulations and ROS indicator DCFH-DA with or without laser irradiation in hypoxic condition; (G) Time-dependent tumor growth curves; (H) average weights of the excited tumors at the end of the indicated treatment. Reprinted from ref.^[94] with permission. *P < 0.05; ***P < 0.001; ^###P < 0.001. Copyright 2022, BMC.