fig4

Figure 4. Protein-protein interaction (PPI) network with known genes of cell fate and cell survival regulatory pathways. MYC, CTNNB1, GSK3B, SHH, GLI2, AXIN1, EGFR, GLI3, NOTCH1 and RBPJ are identified as the top 10 hub proteins using the Bottleneck method. Among these proteins, MYC, CTNNB1 and GSK3B appeared as the most connected hub proteins in the network. Color bar indicates high (red) to low (yellow) connectivity of the protein hubs.