fig3

Figure 3. Summary of deregulation of cell fate and cell survival regulatory pathways under the influence of HR-HPVs during cervical cancer initiation and development. The cell regulatory systems are generally destabilized by HR-HPV oncoproteins, while the cell fate regulators are disrupted primarily by genetic and/or epigenetic alterations. Both systems cooperate to aberrantly transform healthy cervical cells and deregulate cell cycle progression. Created with BioRender.com.