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Figure 1. Cell fate regulatory canonical Hedgehog, Wnt and Notch signaling pathways in cervical cancer. (A) "OFF STATE” describes the cytoplasmic stabilization of GSK3β followed by proteasomal degradation or cytoplasmic restriction of the effector molecules; GLI^A, β-catenin and NICD for the three pathways, respectively, in the absence of ligands or in the presence of antagonists. As a result, no target genes are expressed. (B) "ON STATE” describes the inactivation of cytoplasmic GSK3β by the influence of suitable ligands. This helps in the nuclear translocation of effector molecules and the expression of their target genes. Created with BioRender.com.