REFERENCES
2. Najafi M, Goradel NH, Farhood B, et al. Tumor microenvironment: interactions and therapy. J Cell Physiol 2019;234:5700-21.
3. Yan H, Ramirez-Guerrero D, Lowengrub J, Wu M. Stress generation, relaxation and size control in confined tumor growth. PLoS Comput Biol 2021;17:e1009701.
4. Purkayastha P, Jaiswal MK, Lele TP. Molecular cancer cell responses to solid compressive stress and interstitial fluid pressure. Cytoskeleton 2021;78:312-22.
5. Nia HT, Munn LL, Jain RK. Mapping physical tumor microenvironment and drug delivery. Clin Cancer Res 2019;25:2024-6.
6. Hayward MK, Muncie JM, Weaver VM. Tissue mechanics in stem cell fate, development, and cancer. Dev Cell 2021;56:1833-47.
7. Northey JJ, Przybyla L, Weaver VM. Tissue force programs cell fate and tumor aggression. Cancer Discov 2017;7:1224-37.
8. Ayad NME, Kaushik S, Weaver VM. Tissue mechanics, an important regulator of development and disease. Philos Trans R Soc Lond B Biol Sci 2019;374:20180215.
9. Barnes JM, Przybyla L, Weaver VM. Tissue mechanics regulate brain development, homeostasis and disease. J Cell Sci 2017;130:71-82.
10. Levayer R. Solid stress, competition for space and cancer: the opposing roles of mechanical cell competition in tumour initiation and growth. Semin Cancer Biol 2020;63:69-80.
11. Han SJ, Kwon S, Kim KS. Contribution of mechanical homeostasis to epithelial-mesenchymal transition. Cell Oncol 2022;45:1119-36.
12. Wang J, He Y, Yang G, Li N, Li M, Zhang M. Transient receptor potential canonical 1 channel mediates the mechanical stress-induced epithelial-mesenchymal transition of human bronchial epithelial (16HBE) cells. Int J Mol Med 2020;46:320-30.
13. Jang I, Beningo KA. Integrins, CAFs and mechanical forces in the progression of cancer. Cancers 2019;11:721.
14. Martinez A, Buckley M, Scalise CB, et al. Understanding the effect of mechanical forces on ovarian cancer progression. Gynecol Oncol 2021;162:154-62.
15. Bertolio R, Napoletano F, Del Sal G. Dynamic links between mechanical forces and metabolism shape the tumor milieu. Curr Opin Cell Biol 2023;84:102218.
16. Montagner M, Dupont S. Mechanical forces as determinants of disseminated metastatic cell fate. Cells 2020;9:250.
17. Bertero T, Gaggioli C. Mechanical forces rewire metabolism in the tumor niche. Mol Cell Oncol 2019;6:1592945.
18. Bregenzer ME, Horst EN, Mehta P, Novak CM, Repetto T, Mehta G. The role of cancer stem cells and mechanical forces in ovarian cancer metastasis. Cancers 2019;11:1008.
19. van Helvert S, Storm C, Friedl P. Mechanoreciprocity in cell migration. Nat Cell Biol 2018;20:8-20.
20. Butcher DT, Alliston T, Weaver VM. A tense situation: forcing tumour progression. Nat Rev Cancer 2009;9:108-22.
21. Nagelkerke A, Bussink J, Rowan AE, Span PN. The mechanical microenvironment in cancer: how physics affects tumours. Semin Cancer Biol 2015;35:62-70.
23. Young KM, Reinhart-King CA. Cellular mechanosignaling for sensing and transducing matrix rigidity. Curr Opin Cell Biol 2023;83:102208.
24. Li X, Wang J. Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis. Int J Biol Sci 2020;16:2014-28.
25. Najafi M, Farhood B, Mortezaee K. Extracellular matrix (ECM) stiffness and degradation as cancer drivers. J Cell Biochem 2019;120:2782-90.
26. Sahai E, Astsaturov I, Cukierman E, et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer 2020;20:174-86.
27. Dorbala S. Fibroblast activation: a novel mechanism of heart failure in light chain cardiac amyloidosis? JACC Cardiovasc Imaging 2022;15:1971-3.
28. Kalli M, Papageorgis P, Gkretsi V, Stylianopoulos T. Solid stress facilitates fibroblasts activation to promote pancreatic cancer cell migration. Ann Biomed Eng 2018;46:657-69.
29. Peng Z, Lv X, Zhang P, et al. Intercellular interactions mediated by HGF and TGF-Β promote the 3D spherical and xenograft growth of liver cancer cells. Curr Protein Pept Sci 2024;25:71-82.
30. Chiew GGY, Fu A, Perng Low K, Qian Luo K. Physical supports from liver cancer cells are essential for differentiation and remodeling of endothelial cells in a HepG2-HUVEC co-culture model. Sci Rep 2015;5:10801.
31. Gerarduzzi C, Di Battista JA. Myofibroblast repair mechanisms post-inflammatory response: a fibrotic perspective. Inflamm Res 2017;66:451-65.
32. Ansardamavandi A, Tafazzoli-Shadpour M. The functional cross talk between cancer cells and cancer associated fibroblasts from a cancer mechanics perspective. Biochim Biophys Acta Mol Cell Res 2021;1868:119103.
33. Zhang Q, Peng C. Cancer-associated fibroblasts regulate the biological behavior of cancer cells and stroma in gastric cancer. Oncol Lett 2018;15:691-8.
34. Ping Q, Yan R, Cheng X, et al. Cancer-associated fibroblasts: overview, progress, challenges, and directions. Cancer Gene Ther 2021;28:984-99.
35. Houthuijzen JM, Jonkers J. Cancer-associated fibroblasts as key regulators of the breast cancer tumor microenvironment. Cancer Metastasis Rev 2018;37:577-97.
36. Peng Z, Hao M, Tong H, et al. The interactions between integrin α5β1 of liver cancer cells and fibronectin of fibroblasts promote tumor growth and angiogenesis. Int J Biol Sci 2022;18:5019-37.
37. An J, Hong H, Won M, et al. Mechanical stimuli-driven cancer therapeutics. Chem Soc Rev 2023;52:30-46.
38. Ribatti D. A revisited concept: contact inhibition of growth. From cell biology to malignancy. Exp Cell Res 2017;359:17-9.
39. Gérard C, Goldbeter A. The balance between cell cycle arrest and cell proliferation: control by the extracellular matrix and by contact inhibition. Interface Focus 2014;4:20130075.
42. Venkatesh SK, Yin M, Glockner JF, et al. MR elastography of liver tumors: preliminary results. AJR Am J Roentgenol 2008;190:1534-40.
43. Wells PN, Liang HD. Medical ultrasound: imaging of soft tissue strain and elasticity. J R Soc Interface 2011;8:1521-49.
44. Grady ME, Composto RJ, Eckmann DM. Cell elasticity with altered cytoskeletal architectures across multiple cell types. J Mech Behav Biomed Mater 2016;61:197-207.
45. Rotsch C, Radmacher M. Drug-induced changes of cytoskeletal structure and mechanics in fibroblasts: an atomic force microscopy study. Biophys J 2000;78:520-35.
46. Park S, Koch D, Cardenas R, Käs J, Shih CK. Cell motility and local viscoelasticity of fibroblasts. Biophys J 2005;89:4330-42.
47. Evans DW, Moran EC, Baptista PM, Soker S, Sparks JL. Scale-dependent mechanical properties of native and decellularized liver tissue. Biomech Model Mechanobiol 2013;12:569-80.
48. The Physical Sciences - Oncology Centers Network. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep 2013;3:1449.
49. Xu W, Mezencev R, Kim B, Wang L, McDonald J, Sulchek T. Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells. PLoS One 2012;7:e46609.
50. Mashanov GI, Molloy JE. Automatic detection of single fluorophores in live cells. Biophys J 2007;92:2199-211.
51. Pelipenko J, Kocbek P, Kristl J. Nanofiber diameter as a critical parameter affecting skin cell response. Eur J Pharm Sci 2015;66:29-35.
52. Rubtsova SN, Zhitnyak IY, Gloushankova NA. Phenotypic plasticity of cancer cells based on remodeling of the actin cytoskeleton and adhesive structures. Int J Mol Sci 2021;22:1821.
53. Labernadie A, Kato T, Brugués A, et al. A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion. Nat Cell Biol 2017;19:224-37.
54. Vilchez Mercedes SA, Bocci F, Levine H, Onuchic JN, Jolly MK, Wong PK. Decoding leader cells in collective cancer invasion. Nat Rev Cancer 2021;21:592-604.
55. Ebrahim S, Liu J, Weigert R. The actomyosin cytoskeleton drives micron-scale membrane remodeling in vivo via the generation of mechanical forces to balance membrane tension gradients. Bioessays 2018;40:e1800032.
56. Jain RK, Martin JD, Stylianopoulos T. The role of mechanical forces in tumor growth and therapy. Annu Rev Biomed Eng 2014;16:321-46.
57. Zhang Y, Yu J, Bomba HN, Zhu Y, Gu Z. Mechanical force-triggered drug delivery. Chem Rev 2016;116:12536-63.
58. Broders-Bondon F, Nguyen Ho-Bouldoires TH, Fernandez-Sanchez ME, Farge E. Mechanotransduction in tumor progression: the dark side of the force. J Cell Biol 2018;217:1571-87.
59. Barbazan J, Pérez-González C, Gómez-González M, et al. Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction. Nat Commun 2023;14:6966.
60. Miyazaki K, Oyanagi J, Hoshino D, Togo S, Kumagai H, Miyagi Y. Cancer cell migration on elongate protrusions of fibroblasts in collagen matrix. Sci Rep 2019;9:292.
61. Goldmann WH, Auernheimer V, Thievessen I, Fabry B. Vinculin, cell mechanics and tumour cell invasion. Cell Biol Int 2013;37:397-405.
62. Wirtz D, Konstantopoulos K, Searson PC. The physics of cancer: the role of physical interactions and mechanical forces in metastasis. Nat Rev Cancer 2011;11:512-22.
63. Rahaman SG, Mahanty M, Mukherjee P, Dutta B, Rahaman SO. Mechanosensing and mechanosignal transduction in atherosclerosis. Curr Atheroscler Rep 2023;25:711-21.
64. Wang L, Zheng F, Song R, et al. Integrins in the regulation of mesenchymal stem cell differentiation by mechanical signals. Stem Cell Rev Rep 2022;18:126-41.
65. Graf F, Horn P, Ho AD, Boutros M, Maercker C. The extracellular matrix proteins type I collagen, type III collagen, fibronectin, and laminin 421 stimulate migration of cancer cells. FASEB J 2021;35:e21692.
66. Inman A, Smutny M. Feeling the force: multiscale force sensing and transduction at the cell-cell interface. Semin Cell Dev Biol 2021;120:53-65.
67. Mège RM, Ishiyama N. Integration of cadherin adhesion and cytoskeleton at adherens junctions. Cold Spring Harb Perspect Biol 2017;9:a028738.
68. Gloushankova NA, Rubtsova SN, Zhitnyak IY. Cadherin-mediated cell-cell interactions in normal and cancer cells. Tissue Barriers 2017;5:e1356900.
69. Castellanos-Martín A, Castillo-Lluva S, Sáez-Freire Mdel M, et al. Unraveling heterogeneous susceptibility and the evolution of breast cancer using a systems biology approach. Genome Biol 2015;16:40.
70. Saini K, Discher DE. Forced unfolding of proteins directs biochemical cascades. Biochemistry 2019;58:4893-902.
71. Moore SW, Zhang X, Lynch CD, Sheetz MP. Netrin-1 attracts axons through FAK-dependent mechanotransduction. J Neurosci 2012;32:11574-85.
72. Zuidema A, Wang W, Sonnenberg A. Crosstalk between cell adhesion complexes in regulation of mechanotransduction. Bioessays 2020;42:e2000119.
73. Lessey EC, Guilluy C, Burridge K. From mechanical force to RhoA activation. Biochemistry 2012;51:7420-32.
74. Angulo-Urarte A, van der Wal T, Huveneers S. Cell-cell junctions as sensors and transducers of mechanical forces. Biochim Biophys Acta Biomembr 2020;1862:183316.
75. Li C, Qiu S, Liu X, et al. Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling. Signal Transduct Target Ther 2023;8:247.
76. Gaggioli C, Hooper S, Hidalgo-Carcedo C, et al. Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol 2007;9:1392-400.
77. Hebner C, Weaver VM, Debnath J. Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures. Annu Rev Pathol 2008;3:313-39.
78. Guan X, Guan X, Dong C, Jiao Z. Rho GTPases and related signaling complexes in cell migration and invasion. Exp Cell Res 2020;388:111824.
79. Xie X, Kaoud TS, Edupuganti R, et al. c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun. Oncogene 2017;36:2599-608.
80. Finegan TM, Bergstralh DT. Division orientation: disentangling shape and mechanical forces. Cell Cycle 2019;18:1187-98.
81. Provenzano PP, Keely PJ. Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling. J Cell Sci 2011;124:1195-205.
82. Ma S, Meng Z, Chen R, Guan KL. The hippo pathway: biology and pathophysiology. Annu Rev Biochem 2019;88:577-604.
83. Zhang C, Wang F, Gao Z, Zhang P, Gao J, Wu X. Regulation of hippo signaling by mechanical signals and the cytoskeleton. DNA Cell Biol 2020;39:159-66.
84. Gerashchenko TS, Novikov NM, Krakhmal NV, et al. Markers of cancer cell invasion: are they good enough? J Clin Med 2019;8:1092.
85. Tse JM, Cheng G, Tyrrell JA, et al. Mechanical compression drives cancer cells toward invasive phenotype. Proc Natl Acad Sci USA 2012;109:911-6.
86. Mierke CT. The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells. Rep Prog Phys 2019;82:064602.
87. Liang Y, Zhang H, Song X, Yang Q. Metastatic heterogeneity of breast cancer: molecular mechanism and potential therapeutic targets. Semin Cancer Biol 2020;60:14-27.
88. Kumar S, Weaver VM. Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Cancer Metastasis Rev 2009;28:113-27.
89. DeLeon-Pennell KY, Barker TH, Lindsey ML. Fibroblasts: the arbiters of extracellular matrix remodeling. Matrix Biol 2020;91-2:1-7.
90. Ying F, Chan MSM, Lee TKW. Cancer-associated fibroblasts in hepatocellular carcinoma and cholangiocarcinoma. Cell Mol Gastroenterol Hepatol 2023;15:985-99.
91. Mandal K, Gong Z, Rylander A, Shenoy VB, Janmey PA. Opposite responses of normal hepatocytes and hepatocellular carcinoma cells to substrate viscoelasticity. Biomater Sci 2020;8:1316-28.
92. Katira P, Bonnecaze RT, Zaman MH. Modeling the mechanics of cancer: effect of changes in cellular and extra-cellular mechanical properties. Front Oncol 2013;3:145.
93. Riehl BD, Park JH, Kwon IK, Lim JY. Mechanical stretching for tissue engineering: two-dimensional and three-dimensional constructs. Tissue Eng Part B Rev 2012;18:288-300.
94. Yang L, Yang Y, Wang S, Li Y, Zhao Z. In vitro mechanical loading models for periodontal ligament cells: from two-dimensional to three-dimensional models. Arch Oral Biol 2015;60:416-24.