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![Mechanical force-mediated interactions between cancer cells and fibroblasts and their role in the progression of hepatocellular carcinoma](https://image.oaes.cc/cf6a2790-78a2-40bb-beb8-44550b43feb8/jcmt100137.fig.3.jpg)
Figure 3. Diagram depicting the main effects of tensional force applied on tissues/cells. Tensional stress is the kind of force applied perpendicular to cells, resulting in expansion, which is usually generated after the formation of adhesion junctions with other cells. In addition to the direct adhesion junctions formed by cadherin, there are indirect adhesion interactions mediated by ECM proteins.