fig1

Figure 1. Kaplan-Meier estimates of OS and TTFT according to FISH clonal evolution. (A) OS analysis in patients treated at least 3 months after the first FISH sample. Patients who did not acquire karyotypic abnormalities in the second FISH panel are represented in blue. Patients who acquired karyotypic abnormalities in the second FISH panel compared to the first FISH panel are represented in red. (B) TTFT analysis in patients treated after the second FISH sample. Patients who did not acquire karyotypic abnormalities in the second FISH panel are represented in blue. Patients who acquired karyotypic abnormalities in the second FISH panel compared to the first FISH panel are represented in red. P-value is represented by adjacent curves.