fig3

Figure 3. The activation of the RSK family. The RSK protein kinases undergo activation through direct phosphorylation triggered by the Ras/MAPK pathway. This activation can be impeded by inhibiting MEK (PD98059, PD184352 and U0126), ERK (SCH772984) and the RSK family itself (SL0101, BI-D1870, LJH685, LJI308, BIX02565 and FMK).