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![The role of pro-inflammatory components, carcinoma-associated fibroblasts, and tumor-associated macrophages in ovarian cancer progression and metastasis](https://image.oaes.cc/0cd7f5c0-d967-4b8f-914f-ebb5d958cb7c/5448.fig.1.jpg)
Figure 1. The ovarian TME. The release of pro-inflammatory cytokines by tumor tissue makes the TME inflammatory, with the recruitment of immune cells and the differentiation of fibroblasts and macrophages into tumor-associated cells. These processes induce a malignant transformation causing epithelial-mesenchymal transition and infiltration of tumor cells favoring their progression, invasion, and metastasis.