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Figure 2. LPA activity in bone metastasis microenvironment: overview of actions of lysophosphatidic acid (LPA) on bone cells, cancer cells, and neurons. Black arrows indicate LPA activity on different cell types from the bone microenvironment (names in orange) resulting in multiple biological functions (text in white). Grey arrows indicate LPA or autotaxin (ATX) cell secretion. Dotted black arrows indicate cell differentiation and platelet aggregation. Dotted grey arrows indicate LPC catabolism by ATX. LPC: Lysophosphatidylcholine.