fig4
![The antiangiogenic phloroglucinol hyperforin inhibits the secretion of proMMP-2, proMMP-9 and VEGF-A during apoptosis of primary acute myeloid leukemia cells](https://image.oaes.cc/610a56a1-91e6-453c-b38d-bcd4b9d37a4c/4075.fig.4.jpg)
Figure 4. HF inhibits the production of proMMP-2/9 and VEGF-A by AML cells. (A) Total MMP-2 (n = 11), total MMP-9 (n = 8), and VEGF-A (n = 13) productions in the 72-h culture supernatants from AML samples untreated or treated with HF (2 μg/mL) were determined by ELISA. P value was calculated using a Mann-Whitney U-test; *P < 0.05; **P < 0.01. (B) The gelatinolytic activities of MMP-2/9 were analyzed using zymography (see Figure 2) in the supernatants from four AML cell samples treated or not with HF