fig3

Figure 3. Naïve B cells associated with overall survival independent of clinical variables. (A) KM plots showing the association between high and low levels of naïve B cell infiltration and overall survival stratified based on MYC amplification status in the Oberthuer, Rajbhandari, and Westerman datasets (datasets ordered based on sample size). B-L: naïve B-low; B-H: naïve B-high; M-N: MYCN-Normal; M-G: MYCN-Gain; LR-p (MYC-N): P-value calculated by Log-rank tests comparing low and high naïve B infiltration within patients with MYCN-Normal status; LR-p (MYC-G): P-value calculated by Log-rank tests comparing low and high naïve B infiltration within patients with MYCN-Gain status. (B) Forest plots showing the association between naïve B cell infiltration and overall survival in the Oberthuer, Rajbhandari, and Westerman dataset using multivariate Coxph regression models adjusted for stage, age (> 18 months vs. ≤ 18 months), sex (male vs. female), and MYCN amplification status (MYC-Gain vs. MYC-Normal).