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Figure 3. This is a case of diffuse-plus-focal FDG uptake transitioned to focal uptake in a patient with Stage III melanoma. (A) Diffuse-plus-focal FDG uptake (diffuse SUV 8.4, focal SUV 12.8) in the thyroid during treatment with interferon therapy resulting in induced primary hypothyroidism treated with I-T4. (B) FDG uptake regressed after treatment of thyroiditis to a focal area of increased uptake in the left thyroid lobe, SUV 9.8. Final pathology after total thyroidectomy showed multifocal papillary thyroid carcinoma.