fig2

Figure 2. Expression of bone-related genes in calvaria treated with CM or control. Graphs represent the fold changes of mRNA expression of RUNX2, OSX, ALPL, RANKL, OPG, OCN, IBSP, PTH1R, OMD, ON, MMP9, and CTSK in (A) Ace-1 CM-treated calvaria relative to control; (B) LuMa CM-treated calvaria relative to control; (C) Probasco CM-treated calvaria relative to control; (D) Probasco CM-treated calvaria relative to Ace-1 CM-treated calvaria; (E) LuMa CM-treated calvaria relative to Ace-1 CM-treated calvaria; and (F) Probasco CM-treated calvaria relative to LuMa CM-treated calvaria. Data were expressed as mean ± SD. Significant differences were marked with asterisks (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). Note differences in the scales of the Y axes. CM: Conditioned medium.