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![Overview of genetic signaling pathway interactions within cutaneous malignancies](https://image.oaes.cc/8a9341d6-b017-424c-ba47-0946ec31458f/3676.fig.5.jpg)
Figure 5. SHH pathway increases intracellular calcium, which can also increase the activation of EGFR. SHH also activates MMPs, which will activate the EGFR and increase cellular growth[71]. SHH: sonic hedgehog; EGFR: epidermal growth factor receptor; MMP: metalloproteinases; NF-κB: nuclear factor-kappa B