fig11
![Overview of genetic signaling pathway interactions within cutaneous malignancies](https://image.oaes.cc/8a9341d6-b017-424c-ba47-0946ec31458f/3676.fig.11.jpg)
Figure 11. Multifactorial reprogramming to acidification of melanoma tumor microenvironment. The pH and oxygen microenvironment work together with genetic and metabolic pathways to promote melanoma proliferation and metastasis progression[176]. HIF-1α: hypoxia-inducible factor-1 alpha; mTOR: mammalian target of rapamycin