fig10

Figure 10. Schematic of the μNMR system. TCO-labeled antibodies are added to whole blood. Red blood cells are then lysed and the cells spun down before reaction with tetrazine-modified MNPs. The process of labeling antibodies and targeting nanoparticles requires less than 30 min. Biomarker measurements are then taken using the μNMR device (A); Biomarker expression, as assessed by μNMR, showed that significant percentages of cancer patients (n = 58) were negative for EpCAM (34.4%), HER-2 (32.7%), MUC-1 (32.7%), and EGFR (31.0%). Combining these markers, however, enabled identification of nearly all cancer patients (99.2%) (B)^[95]. Reprinted with permission from Elsevier. μNMR: micro nuclear magnetic resonance; EpCAM: epithelial cell adhesion molecule; HER-2: human epidermal growth factor receptor 2; MUC-1: mucin 1; EGFR: epidermal growth factor receptor