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![Genetic characteristics and molecular diagnostics of bone tumors](https://image.oaes.cc/377a4309-21bc-4666-8d25-765aab053652/3898.fig.8.jpg)
Figure 8. MDM2 amplification by FISH: representative example of supernumerary ring chromosome formation containing amplified material from 12q13-15. Increased copy numbers of MDM2 (red probe) signals (black arrow) are seen within ringed chromosomes (Image courtesy of Dr. Christine Bryke MD, Beth Israel Deaconess Medical Center). FISH: fluorescence in situ hybridization