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![Glycogen synthase kinase 3β biology in bone and soft tissue sarcomas](https://image.oaes.cc/75464bb3-86d4-4087-aabd-d1cf45ea8fdc/3820.fig.1.jpg)
Figure 1. Reported mechanisms by which GSK3β promotes (→) the development of osteosarcoma and rhabdomyosarcoma, while suppressing (—|) osteogenesis and skeletal musculogenesis. →: promoting; —|: suppressive; GSK3β: glycogen synthase kinase 3β; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; FOXO1: forkhead box O-subfamily 1; PAX3: paired box 3