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![Cyclophosphamide, fluorouracil and low-dose interleukin-2 and salvage combination chemotherapy in advanced cutaneous squamous cell carcinoma](https://image.oaes.cc/25ab5e1a-403f-4558-951d-d629e3280ecd/3518.fig.4.jpg)
Figure 4. Outcome of complete and differential blood count and immunophenotyping during chemo-immunotherapy and salvage chemotherapy. A: The blood count showed an initial increase in white blood cells (WBC), neutrophilic granulocytes (N) and lymphocytes (Lym) followed by their decrease during chemo-immunotherapy; B: An undulating trend of CD3+, CD4+, CD8+, CD19+, CD16+, HLA-DR+ and Tregs and a transient decrease in Treg count were observed after chemo-immunotherapy. Subsequently, after an increase in Treg count, there was a decrease during chemotherapy. CD3+: cluster of differentiation 3 T cell; CD4+: CD4+ (helper) T cell; CD8+: CD8+ (cytotoxic) T cells; CD19+: cluster of differentiation 19 B-lymphocyte; CD16+: type I transmembrane receptor mediating antibody-dependent cellular cytotoxicity (ADCC) by NK cells; HLA-DR+: histocompatibility class II allele T cell; Treg: regulatory T cells CD4(+)CD25(+)Foxp3(+)